Table 4. Correlation between AUC of different DPP-4 inhibitors and kidney function parameters in 5/6N rats.
Kidney function parameters | Alogliptin7 µmol/kg, r2 | Sitagliptin7 µmol/kg, r2 | Linagliptin0.5 µmol/kg, r2 | Linagliptin7 µmol/kg, r2 |
GFR | 0.211 | 0.374* | 0.098 | 0.18 |
Cystatin C | 0.376* | 0.499** | 0.004 | 0.189 |
β2-microglobulin | 0.391* | 0.543** | 0.001 | 0.092 |
NGAL | 0.295 | 0.604** | 0.091 | 0.1 |
Osteopontin | 0.406* | 0.325 | 0.005 | 0.154 |
Correlation analysis between DPP-4 inhibitors and kidney function parameters was performed using Spearman's rank correlation test. N = 6–12 per group.
*p<0.05,
**p<0.01.