. 2011 Nov 18;6(11):e27861. doi: 10.1371/journal.pone.0027861

Table 4. Correlation between AUC of different DPP-4 inhibitors and kidney function parameters in 5/6N rats.

Kidney function parameters	Alogliptin7 µmol/kg, r²	Sitagliptin7 µmol/kg, r²	Linagliptin0.5 µmol/kg, r²	Linagliptin7 µmol/kg, r²
GFR	0.211	0.374^*	0.098	0.18
Cystatin C	0.376^*	0.499^**	0.004	0.189
β₂-microglobulin	0.391^*	0.543^**	0.001	0.092
NGAL	0.295	0.604^**	0.091	0.1
Osteopontin	0.406^*	0.325	0.005	0.154

Correlation analysis between DPP-4 inhibitors and kidney function parameters was performed using Spearman's rank correlation test. N = 6–12 per group.

*p<0.05,

**p<0.01.