Skip to main content
. 2011 Nov 18;6(11):e27921. doi: 10.1371/journal.pone.0027921

Table 4. SNPs associated with patient survival.

SNP/ Center Number of Number of Per-alleleb A/A vs. A/Bb A/A vs. B/Bb A/A vs. A/B+B/Bb
subjectsa deathsa HR (95% CI) p HR (95% CI) p HR (95% CI) p HR (95% CI) p
rs12029406 1q32.1 ( NR5A2 )
Heidelberg 503 418 1.13 (0.99–1.29) 0.07 1.22 (0.99–1.51) 0.06 1.23 (0.92–1.63) 0.16 1.23 (1.01–1.49) 0.04
Liverpool 99 85 0.92 (0.68–1.24) 0.58 1.00 (0.63–1.58) 1.00 0.79 (0.40–1.55) 0.49 0.94 (0.61–1.45) 0.78
rs8028529 15q14 (gene desert)
Heidelberg 508 418 0.84 (0.71–0.99) 0.04 0.73 (0.59–0.91) 0.01 0.93 (0.62–1.41) 0.74 0.76 (0.62–0.93) 0.01
Liverpool 108 93 0.76 (0.55–1.05) 0.10 0.96 (0.61–1.51) 0.86 0.40 (0.16–1.01) 0.05 0.80 (0.52–1.22) 0.30
a

Numbers may not add up to 100% of subjects due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to two additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.

b

HR: hazard ratio; CI: confidence interval. Age and gender did not show statistically significant association with survival, therefore were not used as adjustment variables. Associations approaching statistical significance are reported in bold.