Table 4. SNPs associated with patient survival.
SNP/ Center | Number of | Number of | Per-alleleb | A/A vs. A/Bb | A/A vs. B/Bb | A/A vs. A/B+B/Bb | ||||
subjectsa | deathsa | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
rs12029406 1q32.1 ( NR5A2 ) | ||||||||||
Heidelberg | 503 | 418 | 1.13 (0.99–1.29) | 0.07 | 1.22 (0.99–1.51) | 0.06 | 1.23 (0.92–1.63) | 0.16 | 1.23 (1.01–1.49) | 0.04 |
Liverpool | 99 | 85 | 0.92 (0.68–1.24) | 0.58 | 1.00 (0.63–1.58) | 1.00 | 0.79 (0.40–1.55) | 0.49 | 0.94 (0.61–1.45) | 0.78 |
rs8028529 15q14 (gene desert) | ||||||||||
Heidelberg | 508 | 418 | 0.84 (0.71–0.99) | 0.04 | 0.73 (0.59–0.91) | 0.01 | 0.93 (0.62–1.41) | 0.74 | 0.76 (0.62–0.93) | 0.01 |
Liverpool | 108 | 93 | 0.76 (0.55–1.05) | 0.10 | 0.96 (0.61–1.51) | 0.86 | 0.40 (0.16–1.01) | 0.05 | 0.80 (0.52–1.22) | 0.30 |
Numbers may not add up to 100% of subjects due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to two additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.
HR: hazard ratio; CI: confidence interval. Age and gender did not show statistically significant association with survival, therefore were not used as adjustment variables. Associations approaching statistical significance are reported in bold.