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A-C ClustalW2 alignments of sequence motifs in tail-associated proteins (4A), the active site of P22-like tail spikes (4B), and the C-terminal region of P22-like tail spikes-yellow-sequence motif (residues 585-596 in P22) associated with intertwined region, green-five-stranded β-sheet and three-stranded β-sheet (residues 601-664 in P22), and red-regions lacking homology in ΦSH19 Tsp3 (4C).
