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IL-4-induced macrophage fusion and FBGC formation features maintained expression of CD68, CD98 and αXβ2 integrin, de novo appearance of DC-SIGN, and down-modulation of CD14. Significantly, FBGC formation is accompanied by re-expression of HLA-DR and de novo expression of B7-2 and B7-H1, which may provide opportunities for interactions with lymphocytes that, in the case of B7-H1, result in lymphocyte down-modulation.
