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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Hypertension. 2011 Oct 17;58(6):1073–1078. doi: 10.1161/HYPERTENSIONAHA.111.176370

Table 2.

Association of SCNN1G SNPs rs13331086 and blood pressure by inverse variance weighted fixed effects meta-analysis

Cohort n SBP DBP
β SE P β SE P
VFHS 2876 0.81 0.46 0.01 0.37 0.29 0.58
UPS 1274 0.69 0.86 0.42 1.09 0.57 0.05
GRAPHIC 2020 1.12 0.60 0.06 0.27 0.36 0.45
SHS 583 4.25 1.74 0.02 2.53 1.00 0.04
Meta-Analysis 6753 1.01 0.33 0.002 0.52 0.21 0.01

VFHS, Victorian Family Heart Study; UPS, Utah Pedigree Study; GRAPHIC, Genetic Regulation of Arterial Pressure of Humans in the Community cohort; SHS, Silesian Hypertension Study. SBP, systolic blood pressure; DBP, diastolic blood pressure. Individual population β-coefficients (β), Standard Errors (SE), and P values were obtained from GEE-based association tests for quantitative traits for UPS, GRAPHIC and SHS cohorts and from QTLD analysis for VFHS. Combined β, SE and P were obtained using inverse variance meta-analysis in METAL. All P values were obtained after adjustment for hypertension treatment, age, (and age2, age3, where appropriate), sex and BMI. n- number of subjects with complete genotypic and phenotypic information.