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ATP Hydrolysis and Mismatch Binding of MSH2(NΔ25)-MSH6.
| MSH2-MSH6 protein | ATPase Activity No DNA | ATPase Activity G/T DNA | ATPase Activity G/C DNA | DNA Binding | |||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| KM | kcat | KM | kcat | KM | kcat | KD(G/T) | |
|
| |||||||
| μM | min−1 | μM | min−1 | μM | min−1 | nM | |
| wild-type | 9.6 ± 2.1 | 0.7 ± 0.0 | 60.6 ± 17.4 | 10.0 ± 1.1 | 87.9 ± 25.6 | 3. 9 ± 0.5 | 5.98 ± 1.11 |
| NΔ25 | 19.9 ± 5.0 | 0.4 ± 0.0 | 40. 8 ± 5.9 | 5.4 ± 0.2 | 184.4 ± 81.8 | 1.7 ± 0.4 | 9.23 ±2.01 |
