Table 3.
ATP Hydrolysis and Mismatch Binding of MSH2(NΔ25)-MSH3.
| MSH2-MSH3 protein | ATPase Activity (CA)4 DNA | DNA Binding | |
|---|---|---|---|
|
| |||
| KM | kcat | KD(CA)4 | |
|
| |||
| μM | min−1 | nM | |
| wild-type | 7.2 ± 1.4 | 3.3 ± 0.2 | 0.22 ± 0.05 |
| NΔ25 | 8.9 ± 1.8 | 2.7 ± 0.2 | 0.21 ± 0.03 |
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