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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Med Virol. 2011 Nov 3;84(1):152–161. doi: 10.1002/jmv.22147

Table 2.

Quasispecies Complexity and Diversity as a Function of Clinical Status*

Region Complexity Diversity
Viremia/nephropathy Transplanted-viruria Healthy-viruria Viremia/nephropathy Transplanted-viruria Healthy-viruria
Whole VP1 0.54±0.261,a (0.17 – 0.93) 0.81±0.11,c (0.59–0.89) 0.79 ± 0.181,d (0.44–0.97) 0.0015 ± 0.001e (0.0004–0.04) 0.002±0.0011 (0.0007–0.0043) 0.0047±0.0048 (0.0007–0.0152)
BC Loop 0.20 ± 0.18a,b (0–0.59) 0.27 ± 0.18c (0–0.48) 0.31 ± 0.20d (0–0.57) 0.006 ± 0.0072,e (0–0.0253) 0.0019 ± 0.0015 (0–0.0041) 0.0009 ± 0.0222 (0–0.06)
DE Loop 0.06 ± 0.073,a,b (0–0.22) 0.21 ± 0.063,c (0.1–0.26) 0.19 ± 0.16d (0.0002–0.42) 0.002 ± 0.002 (0–0.0078) 0.0022 ± 0.0029 (0–0.0071) 0.003 ± 0.004 (0–0.91)
HI Loop 0.03 ± 0.044,a,b (0–0.11) 0.12 ± 0.084,c (0–0.22) 0.13 ± 0.15d (0–0.42) 0.0013 ± 0.0023e (0–0.0072) 0.0011 ± 0.002 (0–0.0032) 0.0012 ± 0.0021 (0–0.85)
*

Data is presented as mean +/− sd with the range indicated in parentheses. Statistical comparsions between columns are designated by numerical superscripts, while alphabetical designations mark comparisons between rows.

Putative BC loop (nucleotides 169 – 267, Dun numbering, Acc. V01108), DE loop (# 382 – 438), and HI loop (# 805 – 835) were identified using the published literature (40, 41)

1

p<0.05, complexity, Viremia/nephropathy vs both viruria groups in whole VP1 gene.

2

p<0.05, Diversity is significantly higher of BC Loop region in Viremia/nephropathy group than Healthy-viruria Group.

3

p<0.05, Complexity is significantly higher of DE Loop region in Transplanted-viruria group than Viremia/nephropathy group.

4

p<0.05, complexity of the HI Loop is significantly higher in the Transplanted-viruria group than the Viremia/nephropathy group.

a

p<0.05, Complexity, Whole VP1 gene region vs BC Loop, DE Loop, HI Loop of Viremia/nephropathy group.

b

p<0.05 Complexity, BC or DI Loops vs HI Loop in Viremia/nephropathy group.

c

p<0.05, Complexity, whole VP1 gene region vs BC Loop, DE Loop, HI Loop of Transplanted-viruria group.

d

p<0.05, Complexity, whole VP1 gene region vs BC Loop, DE Loop, HI Loop of Healthy-viruria group.

e

p<0.05, Diversity, BC Loop vs whole VP1 and HI Loop in Viremia/nephropathy group.