Table 3.
Sample types * | Final release | Time to 50% release | Model parameters | ||
---|---|---|---|---|---|
ks (hr-1) | koff (hr-1) | ΔG (10-21J) | |||
E | 84.0 ± 2.6% | 10 h | 0.080 | 0.0030 | 5.4 |
M | 71.2 ± 3.2% | 15 h | 0.050 | 0.0033 | 2.5 |
DE | 85.2 ± 4.3% | 22 h | 0.034 | 0.0010 | 7.4 |
EE | 73.0 ± 1.9% | 18 h | 0.040 | 0.0010 | 4.0 |
ME | 66.3 ± 1.7% | 20.5 h | 0.040 | 0.0015 | 2.2 |
DM | 73.9 ± 4.4% | 31.5 h | 0.028 | 0.0018 | 3.5 |
EM | 69.8 ± 2.0% | 48 h | 0.015 | 0.0020 | 3.0 |
MM | 56.4 ± 4.3% | 46 h | 0.018 | 0.0010 | 0.5 |
E: EtOH-treated drug-loaded film without coating; M: MeOH-treated drug-loaded film without coating; DE: Originally non-treated drug-loaded core film with EtOH-treated SELP-47K coating; EE: Originally EtOH-treated drug-loaded core film with EtOH-treated SELP-47K coating; ME: Originally MeOH-treated drug-loaded core film with EtOH-treated SELP-47K coating; DM: Originally non-treated drug-loaded core film with MeOH-treated SELP-47K coating; EM: Originally EtOH-treated drug-loaded core film with MeOH-treated SELP-47K coating; MM: Originally MeOH-treated drug-loaded core film with MeOH-treated SELP-47K coating.