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. Author manuscript; available in PMC: 2012 Nov 18.
Published in final edited form as: ACS Chem Biol. 2011 Sep 8;6(11):1205–1213. doi: 10.1021/cb2001389

Figure 7. Split adaptor systems preserve critical protein-binding interfaces.

Figure 7

(A) Substrate delivery by wild-type SspB requires simultaneous binding between the XB tails of the adaptor and the N-domain of ClpX and between the substrate-binding domain of SspB and a ssrA tag on the substrate. (B) These critical interfaces are preserved in our engineered system but formation of a complete adaptor is under control of rapamycin, a small-molecule inducer of dimerization.