Table 1.
Plasma CETP and (apo)lipoprotein levels in obese patients with type 2 diabetes mellitus and hepatic steatosis in response to 16 weeks of VLCD
Plasma parameters | Baseline | After VLCD | Δ (%) | P value |
---|---|---|---|---|
CETP (μg/mL) | 2.48 ± 0.15 | 2.03 ± 0.14 | −18.2 | 0.0021 |
Total cholesterol (mmol/L) | 5.76 ± 0.30 | 5.00 ± 0.22 | −13.1 | 0.0007 |
Triglycerides (mmol/L) | 2.41 ± 0.28 | 1.32 ± 0.10 | −45.1 | 0.0003 |
Phospholipids (mmol/L) | 2.69 ± 0.11 | 2.28 ± 0.07 | −15.2 | 0.0000 |
LDL-cholesterol (mmol/L) | 3.99 ± 0.27 | 3.36 ± 0.20 | −15.8 | 0.0028 |
ApoB100 (mg/dL) | 130 ± 6 | 111 ± 5 | −13.9 | 0.0016 |
HDL-cholesterol (mmol/L) | 0.84 ± 0.04 | 0.91 ± 0.06 | — | NS |
HDL-phospholipids (mmol/L) | 0.98 ± 0.03 | 0.98 ± 0.05 | — | NS |
ApoAI (mg/dL) | 135 ± 10 | 156 ± 11 | +16.2 | 0.0174 |
Data are presented as means ± SEM (n = 27). Δ values are calculated by comparing values obtained after VLCD with those obtained at baseline from obese patients with type 2 diabetes mellitus. P values are calculated using paired Student t test. NS, not significant.