Table 4.
Combination | Biomarker | T=6h | T=12h | T=24h | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p<0.05 | Δ AUC | NRI | IDI | p<0.05 | Δ AUC | NRI | IDI | p<0.05 | Δ AUC | NRI | IDI | ||
I | NGAL | Yes | 0.013 | 0.64* | 0.10* | Yes | 0.056* | 0.77* | 0.21* | Yes | 0.069* | 0.77* | 0.21* |
IL-18 | Yes | Yes | Yes | ||||||||||
| |||||||||||||
NGAL | Yes | −0.019 | 0.22 | 0.02 | Yes | −0.002 | 0.41* | 0.09* | Yes | 0.005 | 0.34* | 0.08* | |
L-FABP | Yes | Yes | Yes | ||||||||||
| |||||||||||||
NGAL | Yes | −0.007 | 0.48* | 0.01 | Yes | −0.012 | 0.41* | 0.05* | Yes | 0.026 | 0.66* | 0.12* | |
KIM-1 | No | Yes | Yes | ||||||||||
| |||||||||||||
II | NGAL | Yes | 0.009 | 0.60* | 0.11* | Yes | 0.060* | 0.95* | 0.27* | Yes | 0.073* | 0.93* | 0.25* |
IL-18 | Yes | Yes | Yes | ||||||||||
L-FABP | No | Yes | Yes | ||||||||||
| |||||||||||||
NGAL | Yes | 0.013 | 0.56* | 0.10* | Yes | 0.058* | 0.79* | 0.24* | No | 0.084* | 1.00* | 0.27* | |
IL-18 | Yes | Yes | Yes | ||||||||||
KIM-1 | No | Yes | Yes | ||||||||||
| |||||||||||||
NGAL | Yes | −0.003 | 0.21 | 0.03 | Yes | 0.010 | 0.63* | 0.10* | No | 0.045 | 0.84* | 0.15* | |
L-FABP | Yes | Yes | Yes | ||||||||||
KIM-1 | No | Yes | Yes | ||||||||||
| |||||||||||||
III | NGAL | Yes | 0.012 | 0.61* | 0.12* | Yes | 0.064* | 0.98* | 0.28* | No | 0.089* | 1.01* | 0.29* |
IL-18 | Yes | Yes | Yes | ||||||||||
L-FABP | No | Yes | No | ||||||||||
KIM-1 | No | No | Yes |
At 2h, only NGAL was significant
AUC=Area under the Curve, NRI=Net Reclassification Improvement; IDI=Integrated Discrimination Improvement
ΔAUC = Improvement in AUC when compared with the reference model (age + CPB time + NGAL). For NRI, results correspond to % improvement in the performance of the predictive model. For example, NRI=0.64 means 64% improvement over the reference model (i.e. age + CPB time ± NGAL).
p< 0.05