. Author manuscript; available in PMC: 2012 Nov 22.

Published in final edited form as: J Am Coll Cardiol. 2011 Nov 22;58(22):2301–2309. doi: 10.1016/j.jacc.2011.08.017

Table 4.

Summary of biomarker combinations in the model: significance, AUC improvement, NRI and IDI

Combination	Biomarker	T=6h				T=12h				T=24h

		p<0.05	Δ AUC	NRI	IDI	p<0.05	Δ AUC	NRI	IDI	p<0.05	Δ AUC	NRI	IDI

I	NGAL	Yes	0.013	0.64^*	0.10^*	Yes	0.056^*	0.77^*	0.21^*	Yes	0.069^*	0.77^*	0.21^*
	IL-18	Yes	0.013	0.64^*	0.10^*	Yes	0.056^*	0.77^*	0.21^*	Yes	0.069^*	0.77^*	0.21^*

	NGAL	Yes	−0.019	0.22	0.02	Yes	−0.002	0.41^*	0.09^*	Yes	0.005	0.34^*	0.08^*
	L-FABP	Yes	−0.019	0.22	0.02	Yes	−0.002	0.41^*	0.09^*	Yes	0.005	0.34^*	0.08^*

	NGAL	Yes	−0.007	0.48^*	0.01	Yes	−0.012	0.41^*	0.05^*	Yes	0.026	0.66^*	0.12^*
	KIM-1	No	−0.007	0.48^*	0.01	Yes	−0.012	0.41^*	0.05^*	Yes	0.026	0.66^*	0.12^*

II	NGAL	Yes	0.009	0.60^*	0.11^*	Yes	0.060^*	0.95^*	0.27^*	Yes	0.073^*	0.93^*	0.25^*
	IL-18	Yes				Yes				Yes
	L-FABP	No				Yes				Yes

	NGAL	Yes	0.013	0.56^*	0.10^*	Yes	0.058^*	0.79^*	0.24^*	No	0.084^*	1.00^*	0.27^*
	IL-18	Yes				Yes				Yes
	KIM-1	No				Yes				Yes

	NGAL	Yes	−0.003	0.21	0.03	Yes	0.010	0.63^*	0.10^*	No	0.045	0.84^*	0.15^*
	L-FABP	Yes				Yes				Yes
	KIM-1	No				Yes				Yes

III	NGAL	Yes	0.012	0.61^*	0.12^*	Yes	0.064^*	0.98^*	0.28^*	No	0.089^*	1.01^*	0.29^*
	IL-18	Yes				Yes				Yes
	L-FABP	No				Yes				No
	KIM-1	No				No				Yes

At 2h, only NGAL was significant

AUC=Area under the Curve, NRI=Net Reclassification Improvement; IDI=Integrated Discrimination Improvement

ΔAUC = Improvement in AUC when compared with the reference model (age + CPB time + NGAL). For NRI, results correspond to % improvement in the performance of the predictive model. For example, NRI=0.64 means 64% improvement over the reference model (i.e. age + CPB time ± NGAL).

p< 0.05