. Author manuscript; available in PMC: 2012 Nov 15.

Published in final edited form as: Cancer Cell. 2011 Nov 15;20(5):591–605. doi: 10.1016/j.ccr.2011.09.011

Table 2.

Gene sets enriched in BM CD34+ cells from patients at time of development of t-MDS/AML

	NES	FDR q-val
*Enriched in Cases*
G-Protein coupled receptors
HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	3.11	<0.001
GPCRDB_CLASS_A_RHODOPSIN_LIKE	2.70	<0.001
GPCRS_CLASS_A_RHODOPSIN_LIKE	2.69	<0.001
MONOAMINE_GPCRS	2.50	<0.001
PEPTIDE_GPCRS	1.80	0.143
Cell adhesion/communication
HSA01430_CELL_COMMUNICATION	2.59	<0.001
HSA04512_ECM_RECEPTOR_INTERACTION	2.22	0.001
HSA04514_CELL_ADHESION_MOLECULES	1.94	0.016
Hematopoietic regulation
HSA04340_HEDGEHOG_SIGNALING_PATHWAY	2.04	0.012
*Enriched in controls (reduced in cases)*
Cell cycle regulation/checkpoints
SERUM_FIBROBLAST_CELLCYCLE	−3.34	<0.001
DNA_REPLICATION_REACTOME	−3.15	<0.001
P21_P53_ANY_DN	−3.12	<0.001
P21_P53_MIDDLE_DN	−2.87	<0.001
CELL_CYCLE	−2.77	<0.001
CELL_CYCLE_KEGG	−2.70	<0.001
HSA04110_CELL_CYCLE	−2.63	<0.001
DNA_DAMAGE_SIGNALING	−2.45	<0.001
GOLDRATH_CELLCYCLE	−2.42	0.002
Hematopoietic stem cells
HSC_LATEPROGENITORS_ADULT	−2.60	<0.001
HSC_LATEPROGENITORS_SHARED	−2.58	<0.001
HSC_LATEPROGENITORS_FETAL	−2.57	<0.001
HSC_INTERMEDIATEPROGENITORS_ADULT	−2.51	<0.001
HSC_EARLYPROGENITORS_SHARED	−2.47	<0.001
HSC_INTERMEDIATEPROGENITORS_SHARED	−2.39	<0.001
Metabolism
PENG_LEUCINE_DN	−2.56	<0.001
KREBS_TCA_CYCLE	−2.55	<0.001
PENG_GLUTAMINE_DN	−2.43	<0.001
HSA00020_CITRATE_CYCLE	−2.26	<0.001
Mitochondria and oxidative phosphorylation
MITOCHONDRIA	−2.66	<0.001
HUMAN_MITODB_6_2002	−2.58	<0.001
ELECTRON_TRANSPORT_CHAIN	−2.42	<0.001
Proteasome pathway
PROTEASOMEPATHWAY	−2.30	<0.001
PROTEASOME	−2.16	<0.001
DNA repair
BRENTANI_REPAIR	−2.91	<0.001