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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Cancer Cell. 2011 Nov 15;20(5):661–673. doi: 10.1016/j.ccr.2011.10.012

Figure 1. CML hematopoiesis in inducible BCR/ABL transgenic mice.

Figure 1

(A) Experimental scheme. Double transgenic mice (BA) were maintained in presence of doxycycline (20mg/L) in drinking water until 5 weeks of age before inducting BCR/ABL by doxycycline withdrawal. Wild type and single transgenic littermates treated with the same regimen were used as controls (Cnt) and all the mice were analyzed 6 weeks after doxycycline withdrawal.

(B) Hematopoietic features in CML mice. Graphs show the percentages of mature cells detected in PB, BM and spleen of Cnt and BA mice. Results are expressed as mean ± SD (n≥8; *p≤10-2, **p≤10-3, ***p≤10-4).

(C) Weight, morphology and hematoxylin and eosin (H&E) staining of spleen from Cnt and BA mice.

(D) Total cellularity and cell number for each progenitor compartment in BM and spleen of Cnt and BA mice. Results are expressed as mean ± SD (n≥6; *p≤10-2, **p≤10-3, ***p≤10-4, **** p≤10-5).

(E) H&E and (F) Gordon and Sweet's reticulin staining of BM (sternum) section from Cnt and BA mice. The arrowhead indicates myelofibrotic tissue

See also Figure S1.