Figure 4. Reduced levels of eIF5A-1 and DHPS proteins and reduced BrdU incorporation in Eif5agt/gt and Dhpsgt/gt blastocysts (E3.5) cultured in vitro.
The cells from the 7-day in vitro culture of blastocysts (E3.5) were labeled with BrdU. Cell proliferation was estimated from incorporation of BrdU by using anti-BrdU and anti-mouse IgG-fluorescein. To determine the levels of eIF5A-1 and DHPS in these cells, the cells were treated with rabbit polyclonal primary antibodies, anti-eIF5A and anti-DHPS, respectively, and then stained using anti-rabbit IgG-Cy3. DAPI was used for counterstaining of nuclei.
