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Graphic representation of the proposed staging framework for preclinical AD. Note that some individuals will not progress beyond Stage 1 or Stage 2. Individuals in Stage 3 are postulated to be more likely to progress to MCI and AD dementia. Abbreviations: AD, Alzheimer's disease; Ab, amyloid beta; PET, position emission tomography; CSF, cerebrospinal fluid; FDG, fluorodeoxyglucose, fMRI, functional magnetic resonance imaging, sMRI, structural magnetic resonance imaging.
