Figure 6.

Insulin release (nmol l⁻¹ islet⁻¹) (a), islet amyloid severity (% amyloid area/islet area) (b), beta-cell apoptosis (% apoptotic beta cells/total cells) (c) and beta-cell area/islet area (% insulin area/islet area) (d) in non-transgenic (open bars) and hIAPP transgenic (solid bars) islets cultured for 48 hours in 11.1 mmol/l glucose with no drug (control), exendin-4 (10 nmol/l) or KCl (10 mmol/l). *p<0.05 vs. control, n=6. Non-transgenic islets did not form amyloid.