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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Adv Chronic Kidney Dis. 2011 Jan;18(1):28–41. doi: 10.1053/j.ackd.2010.10.003

TABLE 3.

Characteristics and Achieved Blood Pressure in Trials Using Direct Renin Inhibitors as Add-On Therapy in Diabetes

Author Population/Proteinuria Treatment Achieved BP
(mmHg)
Persson
2009

(82) 		DM2
100mg/24h		 Irbesartan
(I)

Aliskiren
(A)

I+A

Placebo		 12/5 reduction
(p<.001/p=.002)

3/4 reduction (DBP
p<.01)

10/6 mmHg reduction
(p<.001/p<.001)

P values vs placebo
Parving
2008

(81) 		DM2

300 mg/g Cr		 Losartan +
Aliskiren

Losartan
+ Placebo		 P=0.07, 0.08 for
SBP, DBP (specific
values not included)
ALTITUDE

(83) 		DM2

High CV Risk		 Aliskiren

Placebo

(Already
on ACEi or
ARB)		 ONGOING

DM2=Diabetes Mellitus Type 2; SBP=Systolic Blood Pressure; DBP=Diastolic Blood Pressure; ACEi=Angiotensin Coverting Enzyme Inhibitor; ARB=Angiotensin Receptor Blocker