Fig. 3.

The ASIC channel blocker amiloride inhibits extracellular [H⁺] evoked currents potentiated by DTT. A. Representative traces. VSMCs pretreated with 1mM DTT for 4 min were exposed to normal external solution ± 100 μM amiloride for 45 sec before exposure to extracellular [H⁺] (pH 6.0). Group data of the effect of amiloride on DTT potentiation of extracellular [H⁺] evoked currents on the normalized peak amplitude (B) and accumulated currents (C, area under curve AUC), (n= 7-9 cells). Note that time references are not drawn to scale. ∗Significantly different, p<0.05.