Fig. 6.

Rac 1 inhibitor NSC23766 (100 μM) potentiates the effect of DTT (1 mM) on extracellular [H⁺] gated currents. A. Representative traces of currents evoked by extracellular [H⁺] (pH 6.0) in VSMCs before DTT pretreatment (control, con), right after 1 min of DTT pretreatment, and after 5 min wash-off of DTT, with (+) or without (-) NSC23766 in the pipette solution. Group data of the effect of 1 mM DTT pretreatment for 1 min on normalized peak amplitude (B) and accumulated currents (C, area under curve, AUC) induced by extracellular [H⁺] without NSC23766, as compared to those with (+) NSC23766 in the pipette solution. (n=11 − 12). ^∗Significantly different, p<0.05.