Fig. 1.

a Ischemia was surgically induced in experimental animals by FSAVPR. In brief, the femoral and saphenous artery (red)-vein (blue) pair was dissected away from the overlying nerve (orange), sutures were placed as indicated (arrowheads), and the intervening length of vessel was resected. b Unilateral loss of limb flow was confirmed by laser Doppler imaging of the surgical (box) and control limb before and 1 day after surgery (scale bar = 1 cm). c A significant decrease in mean surgical limb perfusion (vs. control limb) was observed relative to presurgical scans (∗, n = 8).