Fig. 2.

a–d Representative images taken on day 7 after FSAVPR of the surgical and control limbs of Cx40–/– and WT animals, which demonstrate failure of the Cx40–/– surgical limb to recover. Compared to WT (e), images of the surgical paw of Cx40–/– reveal distal necrosis (f) and autoamputation (g). h Incidence of severe distal necrosis was significantly increased in Cx40–/– animals (71%, 10 of 14) compared to WT (33%, 4 of 12). Necrosis was not observed in any Cx37–/– animals (0%, 0 of 9) following FSAVPR.