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. 2011 May 23;66(12):1029–1035. doi: 10.1136/thx.2010.158568

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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Involvement of prostanoid EP receptors in prostaglandin E₂ (PGE₂)-induced contraction and relaxation of guinea pig tracheal strips. (A) Inhibition of PGE₂-induced contraction under basal tone by the EP₁ antagonist (GW848687X, 1 μM) (PGE₂ + the appropriate vehicle (filled circle) or GW848687X in the presence of PGE₂ (square), n=4–6). (B) Response to selective EP receptor agonists under basal tone (ONO-D1-004 (filled circle), ONO-AE1-259 (circle), ONO-AE-248 (filled square) and ONO-AE1-329 (square)=EP_1–4 respectively, n=4). (C) Inhibition of PGE₂-induced relaxation under induced tone by AH6809 (10 μM, EP₁/EP₂/DP antagonist), (PGE₂ + vehicle (filled circle), PGE₂ + AH6809 (square), n=4). (D) Response to selective EP receptor agonists under induced tone (ONO-AE1-259 (circle), ONO-AE-248 (filled square) and ONO-AE1-329 (square)=EP_2–4 respectively, n=4). Data represent mean±SEM.