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. 2011 May 23;66(12):1029–1035. doi: 10.1136/thx.2010.158568

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

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Involvement of the prostanoid EP receptors in prostaglandin E₂ (PGE₂)-induced relaxation of murine tracheal segments under induced tone. (A) PGE₂-induced relaxation (PGE₂ (filled circle), ethanol vehicle control (circle), n=5). (B) Inhibition of PGE₂-induced relaxation by AH6809 (10 μM, (EP₁/EP₂/DP₁ receptor antagonist). (PGE₂ + vehicle (filled circle), PGE₂ + AH6809 (square), n=4). (C) Effect of specific individual EP receptor gene deficiency on PGE₂-induced relaxation compared with the respective response elicited in wild-type tissues (C57BL/6 wild type (filled circle), Ptger 1^−/− (square), Ptger 2^−/− (filled inverted triangle), Ptger 3^−/− (circle), n=4). (D) Effect of specific individual EP receptor gene deficiency on PGE₂-induced relaxation compared with the respective response elicited in wild-type tissues (129/Ola × C57BL/6 wild type (filled circle), Ptger 4^−/− (circle), n=4). Data represent mean±SEM.