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. 2011 May 23;66(12):1029–1035. doi: 10.1136/thx.2010.158568

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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Involvement of the prostanoid EP receptors in prostaglandin E₂ (PGE₂)-induced relaxation of rat tracheal strips and monkey airway samples under induced tone. (A) Response of rat tracheal strips under induced tone to selective EP receptor agonists (ONO-D1-004 (filled circle), ONO-AE1-259 (circle), ONO-AE-248 (filled square) and ONO-AE1-329 (square)=EP_1–4 respectively, n=3). (B) Inhibition of PGE₂-induced relaxation of rat tracheal strips by ONO-AE3-208 (100 nM) and GW627368X (1 μM) (PGE₂ in the presence of the appropriate vehicle (filled circle), PGE₂ in the presence of ONO-AE3-208 (square) or GW62768X (circle), n=4). (C) Response of Cyno monkey airway samples under induced tone to selective EP receptor agonists (ONO-D1-004 (filled circle), ONO-AE1-259 (circle), ONO-AE-248 (filled square) and ONO-AE1-329 (square)=EP_1-4, respectively, and PGE₂ (filled triangle), n=3). Data represent mean±SEM.