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Cytotoxicity attenuation of intercalating antitumor agents by caffeine.
| Compound |
IC50 (μM)a
|
|
|---|---|---|
| no caffeine | with caffeineb | |
| Berberine | 50.0(4.3) | 511(59) |
| Camptothecin | 9.21(1.41) | 335(31) |
| Chelerythrine | 32.1(0.5) | 37.4(0.8) |
| Doxorubicin | 11.4(2.2) | 31.7(3.9) |
| Ellipticine | 12.8(0.5) | 333(7) |
| Sanguinarine | 5.78(0.22) | 6.66(0.16) |
Standard deviations in parentheses.
Caffeine concentration = 1030 μM.
