Table 3.
Response and overall survival by intratumoral gene expressions
| Marker | N | RECIST response (%) | Overall survival | ||
| Yes | No | Median (95% CI), months | Pa | ||
| COX-2 | |||||
| Above median | 17 | 0 (0) | 17 (100) | 3.2 (2.1–8.7) | 0.24 |
| Below median | 17 | 2 (12) | 15 (88) | 5.0 (3.0–9.9) | |
| Cyclin D1 | |||||
| Above median | 18 | 1 (6) | 17 (94) | 4.9 (3.0–9.2) | 0.89 |
| Below edian | 18 | 2 (11) | 16 (89) | 4.0 (2.7–5.7) | |
| EGFR | |||||
| Above edian | 18 | 2 (11) | 16 (89) | 3.3 (1.9–5.7) | 0.17 |
| Below edian | 17 | 0 (0) | 17 (100) | 5.7 (3.0–8.7) | |
| Her2 | |||||
| Above median | 16 | 2 (13) | 14 (87) | 6.8 (3.3–12.4) | 0.0031 |
| Below median | 17 | 0 (0) | 17 (100) | 3.0 (1.3–4.7) | |
| IL-8 | |||||
| Above median | 17 | 0 (0) | 17 (100) | 3.0 (2.2–5.7) | 0.016 |
| Below median | 18 | 3 (17) | 15 (83) | 5.6 (3.3–10.5) | |
| VEGF | |||||
| Above median | 17 | 1 (6) | 16 (94) | 3.8 (1.1–9.9) | 0.63 |
| Below median | 17 | 1 (6) | 16 (94) | 4.8 (3.0–7.4) | |
a
P values from Cox regression; not adjusted for multiple comparisons.
CI, confidence interval; COX-2, cyclooxygenase-2; EGFR, epidermal growth factor receptor; HER2, human epidermal growth factor receptor 2; IL-8, interleukin 8; VEGF, vascular endothelial growth factor.