Table 3.
Observed Induction and Consolidation Toxicity
| Toxicity | Cycle |
|||
|---|---|---|---|---|
| 1 and 2(n = 31) |
3 Through 6(n = 30) |
|||
| Count | Incidence (%) | Count | Incidence (%) | |
| Induction grade 3 or 4 toxicity* | ||||
| Hemoglobin | 23 | 74.2 | 22 | 73.3 |
| Neutrophils/granulocytes (ANC/AGC) | 25 | 80.6 | 25 | 83.3 |
| Platelets | 24 | 77.4 | 25 | 83.3 |
| Mucositis/stomatitis/colitis/enteritis/diarrhea | 3 | 9.7 | 9 | 30.0 |
| Febrile neutropenia (fever of unknown origin without infection, ANC < 1 × 109; fever ≥ 38.5°C) | 22 | 71.0 | 20 | 66.7 |
| Infection (clinical or microbiologic diagnosis) with grades 3 to 4 neutrophils, ANC < 1.0 × 109 | 3 | 9.7 | 9 | 30.0 |
| Other infection | 0 | 0.0 | 5 | 16.7 |
| Consolidation grade 3, 4, or 5 toxicity (n = 24) * | ||||
| Mucositis/stomatitis/colitis/enteritis/diarrhea | 7 | 29.2 | ||
| Febrile neutropenia (fever of unknown origin without infection, ANC < 1 × 109; fever ≥ 38.5°C) | 8 | 33.3 | ||
| Infection (clinical or microbiologic diagnosis) with grade 3 to 4 neutrophils, ANC < 1.0 × 109 | 11 | 45.8 | ||
| ALT | 13 | 54.2 | ||
| AST | 13 | 54.2 | ||
| Bilirubin (hyperbilirubinemia) | 1 | 4.2 | ||
| Hypoxia | 3 | 12.5 | ||
| Pleural effusion (nonmalignant) | 1 | 4.2 | ||
| Renal failure | 1 | 4.2 | ||
Abbreviations: AGC, absolute granulocyte count; ANC, absolute neutrophil count.
*
Only the maximum grade of toxicity per patient per type of toxicity is counted within the given time period.