Table 3.
Bivariate Analysis of Risk Factors in Stage 4S Metastatic Pattern
| Risk Factor (category of increased risk) | Sample Size | Hazard Ratio | 95% CI | P |
|---|---|---|---|---|
| Age (12 to < 18 months) | 717 | 2.3 | 1.5 to 3.5 | < .001 |
| Age | 564 | NS | .33 | |
| MYCN (amplified) | 4.1 | 2.6 to 6.2 | < .001 | |
| Age | 85 | NS | .30 | |
| 11q (aberration) | 5.0 | 1.6 to 15.7 | .0052 | |
| Age | 196 | NS | .68 | |
| 1p (LOH) | 3.3 | 1.7 to 6.6 | < .001 | |
| Age | 305 | 2.8 | 1.3 to 6.5 | .0127 |
| Ploidy (diploid) | 1.9 | 1.0 to 3.8 | .05 | |
| Age | 337 | NS | .87 | |
| Histologic classification (unfavorable) | 4.3 | 2.2 to 8.4 | < .001 | |
| Age | 296 | 2.4 | 1.2 to 5.0 | .0139 |
| Grade (differentiated) | NS | .77 | ||
| Age | 282 | NS | .67 | |
| MKI (high) | 2.9 | 1.2 to 7.1 | .0183 | |
| Age | 460 | 2.1 | 1.3 to 3.6 | .0040 |
| LDH (≥ 580 U/L) | 2.4 | 1.6 to 3.6 | < .001 | |
| Age | 677 | 2.3 | 1.5 to 3.5 | < .001 |
| Adrenal primary site (Yes) | NS | .59 | ||
| Age | 545 | 2.1 | 1.3 to 3.3 | .0029 |
| Initial treatment (chemotherapy and intensive therapy) | 1.7 | 1.1 to 2.6 | .0161 |
Abbreviations: LDH, lactate dehydrogenase; LOH, loss of heterozygosity; MKI, mitosis-karyorrhexis index; NS, not shown because not statistically significant.