Table A3.

Multivariate Cox Proportional Hazards Model With Covariates of Age and Performance Status for PFS and OS

Model	P*	HR	95% CI
Progression-free survival, n = 48
VEGF model†	.0309	0.904‡	0.825 to 0.991
Age	.0368	0.438	0.202 to 0.951
Performance status§	.0155	2.477	1.188 to 5.166
PDGF model	.1306	0.992	0.981 to 1.002
Age	.0918	0.516	0.239 to 1.113
Performance status§	.0514	2.035	0.996 to 4.158
Overall survival, n = 48
VEGF model†	.0745	0.924‡	0.848 to 1.008
Age	.1172	0.561	0.273 to 1.156
Performance status§	.1591	1.627	0.826 to 3.202
PDGF model	.5853	0.997	0.987 to 1.007
Age	.2846	0.682	0.339 to 1.374
Performance status§	.3506	1.372	0.706 to 2.668

Abbreviations: HR, hazard ratio; PDGF, platelet-derived growth factor; VEGF, vascular endothelial growth factor.

^*All P values are two-sided.

^†There were eight VEGF measurements below the detectable range; therefore, we imputed those values by the lowest value of the VEGF samples measured.

^‡VEGF raw values were divided by 100 to give a more interpretable HR.

^§Performance status indicates Eastern Cooperative Oncology Group performance status of 0 v 1 or 2.