Fig 2.

Follow-up for overall survival began on the date of cancer diagnosis and ended at death or the last day of follow-up (November 1, 2009, for Hawaii; December 31, 2007, for Iowa; and May 31, 2010, for Los Angeles). Median follow-up among surviving patients was 112 months (120 for human papillomavirus–negative [HPV−] and 110 for HPV-positive [HPV+] patients). (A) Kaplan-Meier survival estimates and 95% CIs (shaded area) for patients with HPV+ (solid line) and HPV− (dashed line) oropharyngeal cancer, as determined by the Inno-LiPA assay. (B) Median Kaplan-Meier survival estimates in months (circles) and 95% bootstrap CIs (vertical lines) across four calendar periods for oropharyngeal cancers in 17 registries in the Surveillance, Epidemiology, and End Results (SEER) program and for the 271 tested oropharyngeal cancers, including survival for all oropharyngeal cancers, HPV+ oropharyngeal cancers, and HPV− oropharyngeal cancers. (*) Median survival has not yet been reached. Median survival of oropharyngeal cancers in SEER17 was 25 months during 1984 to 1989, 31.9 months during 1990 to 1994, 43.6 months during 1995 to 1999, and 64.1 months during 2000 to 2004. Median survival of tested patients who had oropharyngeal cancer was 24.1 months during 1984 to 1989, 24.4 months during 1990 to 1994, 56.7 months during 1995 to 1999, and was not yet reached during 2000 to 2004. Median survival of patients who had HPV+ oropharyngeal cancer was 43 months during 1984 to 1989, 37.6 months during 1990 to 1994, 142.2 months during 1995 to 1999, and was not yet reached during 2000 to 2004. Median survival of patients who had HPV− oropharyngeal cancer was 20.9 months during 1984 to 1989, 18.3 months during 1990 to 1994, 27.7 months during 1995 to 1999, and 20.2 months during 2000 to 2004.