Figure 7.

Dp116 has no effect on the maturation or maintenance of the neuromuscular synapse in mdx:utrn^−/− mice. (A) The acetylcholine receptors stained with α-bungarotoxin (αBTX) are continuous in wild-type muscles, but fragmented in mdx:utrn^−/− mice and Dp116:mdx:utrn^−/− muscles. Electron microscopy (EM) images of the neuromuscular synapse shows a reduction in synaptic folds in mdx:utrn^−/− and Dp116:mdx:utrn^−/− muscles compared with wild-type muscles. (B) Quantitative analysis of the data presented in (A) showing that the percent of continuous synapses and the density of folds in the postsynaptic membrane are not increased by expression of Dp116 in mdx:utrn^−/− mice. Bars show the mean ± S.D (*P < 0.001 compared with wild-type mice). Scale bar for images stained with αBTX is 15 μm and for EM images is 1 μm.