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rAAV6-delivered Dp116 does not protect myofibers from dystrophic turnover. mdx:utrn−/− mice were treated with rAAV6-Dp116 at 2 weeks of age. Quadriceps (bottom) and TA (top) were collected and analyzed for Dp116 expression via immunofluorescent staining. At 4 weeks post-injection (left), robust expression of Dp116 is observed. In contrast, Dp116 expression is nearly absent at 10 weeks post-injection (right).
