TABLE 3.
Serum and liver N-Hcy-protein and tHcy levels in Tg-I278T and Tg-hCBS mice
Genotype |
N-Hcy-protein |
tHcy |
||
---|---|---|---|---|
Plasma (μM) | Liver (pmol/mg of protein) | Plasma (μM) | Liver (pmol/mg of protein) | |
Tg-I278T Cbs−/− (n=4) | 16.6 ± 4.1 | 1857 ± 452 | 272 ± 50 | 5680 ± 1777 |
Tg-I278T Cbs+/− (n=2) | 2.62 ± 1.73 | 161 ± 19 | 5.0 ± 2.6 | 110 |
Tg-I278T Cbs+/+ (n=2) | 1.56 ± 0.25 | 163 ± 0.0 | 1.9 ± 1.6 | 75 ± 7.1 |
Tg-hCBS Cbs−/− (n=4) | 10.8 ± 2.1 | 562 ± 132 | 167 ± 40 | 582 ± 326 |
Tg-hCBS Cbs+/− (n=4) | 2.6 ± 0.8 | 165 ± 24 | 6.1 ± 2.4 | 153 ± 21 |