Table 4.
Family histories of BRCA1 c.4034delA and c.5266dupC mutations carriers
| Types of family histories | c.4034delA | c.5266dupC | 95% CI | P-value |
|---|---|---|---|---|
| No data about cancer cases among 1st and 2nd degree relatives | 9% (7) | 22%(28) | 2.44-23.56 | 0.02 |
| At least 3 cancer cases among 1st and 2nd degree relatives (including breast and ovarian) | 48% (38) | 29% (37) | 4.46-33.54 | 0.008 |
| At least 3 cancer cases among 1st and 2nd degree relatives (without breast and ovarian) | 14% (11) | 6% (8) | -2.05-17.45 | 0.08 |
| At least 4 cancer cases among 1st and 2nd degree relatives (including breast and ovarian) | 30% (24) | 15% (19) | 2.14-27.86 | 0.01 |
| Breast cancer families1 | 9% (7) | 24% (31) | 4.25-25.75 | 0.01 |
| Breast and ovarian cancer families2 | 34% (27) | 18% (23) | 2.61-29.39 | 0.01 |
| Total amount of families included | 79 | 128 |
1 - Breast cancer families - all families with at least two 1st or 2nd (related through a man) degree relatives having breast cancer but without ovarian cancer cases in family.
2 - Breast and ovarian cancer families - all families with at least two 1st or 2nd (related through a man) degree relatives having breast or ovarian cancers.