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. Author manuscript; available in PMC: 2011 Nov 21.
Published in final edited form as: Toxicol Appl Pharmacol. 2009 Oct 2;242(1):1–8. doi: 10.1016/j.taap.2009.09.018

Figure 3.

Figure 3

Effect of arginase inhibition on total inflammatory cell number present in lavage fluid in C57BL/6 or NOS2−/− mice exposed to either filtered air (FA) or OVA aerosol. Significant increases in lavage fluid total cell counts were observed in all groups exposed to OVA compared to their corresponding treatment-matched filtered air controls. Administration of nor-NOHA significantly reduced the total airway inflammatory cell burden in OVA-exposed mice compared to vehicle-administered C57BL/6 mice. NOS2−/− mice exposed to OVA had a significantly greater inflammatory cell burden in comparison to the corresponding C57BL/6 mouse groups. Data are presented as mean ± SEM with N, the number of mice in each group, indicated above the column in parentheses. **p<0.01 compared to OVA; ###p<0.01 compared to the corresponding C57BL/6 treatment groups.