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. Author manuscript; available in PMC: 2011 Nov 21.

Published in final edited form as: Toxicol Appl Pharmacol. 2009 Oct 2;242(1):1–8. doi: 10.1016/j.taap.2009.09.018

Effect of arginase inhibition on Arginase1 [A] or Arginase2 [B] content in the airways of C57BL/6 or NOS2−/− mice exposed to OVA aerosol. NOS2−/− animals show significantly greater Arg1 and Arg2 expression in all treatment groups compared to their corresponding C57BL/6 treatment group (p<0.01) except Arg1 OVA. Administration of nor-NOHA apparently decreased Arg1 content in the airways (p=0.0795; two-tailed test). ^##p<0.01, ^###p<0.001 compared to treatment-matched C57BL/6 mice.

Effect of arginase inhibition on Arginase1 [A] or Arginase2 [B] content in the airways of C57BL/6 or NOS2−/− mice exposed to OVA aerosol. NOS2−/− animals show significantly greater Arg1 and Arg2 expression in all treatment groups compared to their corresponding C57BL/6 treatment group (p<0.01) except Arg1 OVA. Administration of nor-NOHA apparently decreased Arg1 content in the airways (p=0.0795; two-tailed test). ^##p<0.01, ^###p<0.001 compared to treatment-matched C57BL/6 mice.