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. 2011 Nov 21;6(11):e25121. doi: 10.1371/journal.pone.0025121

Figure 3. Induction of excessive inflammation in the absence of solTNF during reactivation of M. tuberculosis.

Figure 3

WT (black circles), TNF−/− (white diamonds) and Tm-TNF (white squares) mice were exposed by aerosol inhalation infection to 100–200 CFUs/mouse of M. tuberculosis H37Rv for 3 weeks preceding chemotherapy with 25 mg/Kg INH-RIF for 6 weeks in drinking water. (A) Lung weights were measured at specific time points and BAL derived cell numbers were determined 77 days (B) and 378 days (C) post-infection. The red “T” in the figure corresponds to the drug treatment phase. Data are representative of 1 of 2 experiments performed and are expressed as mean ± SD of 5 mice/group. Significant differences (*p<0.05; **p<0.01; ***p<0.001) were determined by Student's t test for comparisons between two groups and ANOVA for comparisons between three groups.