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. 2011 Nov 21;6(11):e26545. doi: 10.1371/journal.pone.0026545

Figure 2. (A–H): Responses of eight cytokines to specific M. tuberculosis antigens.

Figure 2

Cytokine responses to a peptide cocktail representing early secreted antigenic target-6, culture filtrate protein 10, and TB7.7 (ESAT-6+CFP-10+TB7.7) are depicted for the 12 patients with culture-confirmed tuberculosis (patients) and 12 subjects at low risk for Mtb infection (controls) represented in Table 9. Cytokine concentrations were measured with a custom commercial multiplexed microsphere-based immunoassay (commercial MMIA). Note the split y-axis. The dotted line and value in parentheses represents the mean cytokine response for controls plus three standard deviations, which was used as a cut point to separate positive and negative responses. Panels A through H depict IFN-γ, IL-2, IL-6, IL-8, TNF-α, IP-10, MCP-1, and MIP-1β responses.