Table 3. Comparisons of IFN-γ responses to different antigens measured by commercial ELISA among patients with culture-confirmed tuberculosis.
Cytokine | ESAT-6 | ESAT-6 | ESAT-6 | ESAT-6 | CFP-10 | CFP-10 | CFP-10 | TB7.7 | TB7.7 | ESAT-6+CFP-10 |
vs. | vs. | vs. | vs. | vs. | vs. | vs. | vs. | vs. | vs. | |
CFP-10 | TB7.7 | ESAT-6+CFP-10 | ESAT-6+CFP-10+TB7.7 | TB7.7 | ESAT-6+CFP-10 | ESAT-6+CFP-10+TB7.7 | ESAT-6+CFP-10 | ESAT-6+CFP-10+TB7.7 | ESAT-6+CFP-10+TB7.7 | |
IFN-γ | 61 | 61 | 61 | 61 | 128 | 128 | 128 | 3 | 3 | 187 |
vs. | vs. | vs. | vs. | vs. | vs. | vs. | vs. | vs. | vs. | |
128 | 3 | 187 | 202 | 3 | 187 | 202 | 187 | 202 | 202 | |
(0.794) | (<0.001) | (0.007) | (0.006) | (<0.001) | (0.005) | (0.005) | (<0.001) | (<0.001) | (0.327) |
Median IFN-γ responses (from Table 2) to early secreted antigenic target-6 (ESAT-6), culture filtrate protein 10 (CFP-10), TB7.7, and combinations of these antigens for patients with culture-confirmed tuberculosis (patients) are listed with p values in parenthesis calculated by Mann-Whitney U Rank Sum test. Significant differences (p<0.05) are indicated in bold type.