Figure 2. Time-course of GDNF expression in the rat brain after transduction with the constitutive AAV2-GDNF.

Three doses of the vector were used and striatal levels of GDNF were measured in the tissue homogenates by GDNF ELISA at various time points after transduction. In all three groups, striatal GDNF increased for the first month and was maintained thereafter at a fixed level for 3 more months. The level of expressed GDNF was proportional to the dose of the vector used.