Figure 5. General schedule of rapamycin administration.

Thirty days after vector infusion, rats were randomized into 11 groups of 3 rats. Seven groups received intraperitoneal (i.p.) rapamycin; two groups received oral rapamycin and one group received a direct infusion (CED) of rapamycin into the brain. Control animals (n = 3) received i.p. excipient. The detailed rapamycin dosing regimens are listed in Table 1 .