Table 1. Summary of in vivo GDNF induction from the AAV2-regGDNF after various dosing regimens.

Rapamycin regime	Striatal GDNFng/mg protein
Endogenous GDNF	0
Intraperitoneal administration
A. Vector only	0.05±0.01
B. 1 × (3×10 mg/kg)	0.54±0.25
C. 2 × (3×10 mg/kg)	2.75±0.01
D. 1 × (3×1 mg/kg)	0.1±0.01
E. 3 × (3×1 mg/kg)	0.13±0.02
F. 1 × (3×3 mg/kg)	0.16±0.06
G. 3 × (3×3 mg/kg)	0.80±0.42
H. 6 × (3×3 mg/kg)	1.36±0.3
Oral administration
I. 1×0.5 mg/kg	0.05±0.01
J. 3 × (3×0.5 mg/kg)	0.09±0.05
Direct CED into the brain
K. 2×50 ng	1.26±0.32