Figure 2. Reduced gene dosage of MAPK and insulin pathway genes on sl mutant wings.

Heterozygous mutant conditions for EGF/MAPK (A) and insulin (B) signaling genes, and genes downstream of Sl (C) change the sl ² mutant wing size. Histogram in (D) shows the effects on sl ⁹ mutant wing size of heterozygosity for genes of the insulin and MAPK pathways and of the IP₃R. n = 100 in all cases, * p<0.001; error bars represent SEM. In this and subsequent figures showing genetic interactions, tests were done with hemizygous sl ² or sl ⁹ males and heterozygous or wild type for the genes tested unless otherwise noted.