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. 2011 Nov 21;6(11):e28168. doi: 10.1371/journal.pone.0028168

Figure 1. Knockout mice that selectively lack NMDAR in striatal MSNs have abnormal MSN morphology.

Figure 1

(A) GPR88-CreGFP is expressed selectively in the striatum of knockout animals. A DAPI counterstain was performed. (B) NR1 Western blot of striatal (str) and cortical (cx) homogenates from control and knockout animals. (C) Representative micrographs and tracings of MSNs from control and knockout animals (20 µm scale bar). (D) Cell body size of MSNs in control and knockout mice (n = 18 neurons per genotype); P = 0.009 by unpaired t test; **P<0.01. (E) Total MSN dendrite length in control and knockout mice (n = 18 neurons per genotype); P = 0.002 by unpaired t test; **P<0.01. (F) Number of dendrites by dendrite order in control and knockout mice (n = 18 neurons per genotype); *P<0.05 by unpaired t test. Diagram in (F) depicts the definition of dendrite order.