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. 2011 Nov 21;6(11):e28168. doi: 10.1371/journal.pone.0028168

Figure 2. Knockout mice are smaller than normal but have normal spontaneous locomotion, and intact exploratory behavior.

Figure 2

(A) Spontaneous locomotion by control (n = 10) and knockout (n = 11) animals; light cycle, P = 0.85; dark cycle, P = 0.93; total, P = 0.98 by unpaired t tests. (B). Body weight of 8-week-old animals; control (n = 15) and knockout (n = 12) males, P<0.0001; control (n = 11) and knockout (n = 10) females, P = 0.002 by unpaired t tests; **P<0.01; ***P<0.0001. (C) Locomotor activity of control (n = 10) and knockout (n = 5) animals in an open field; P = 0.17 by unpaired t test. (D) Fraction of time spent in the center and periphery of the open field by control (n = 10) and knockout (n = 5) animals; P = 0.08 by unpaired t tests. (E) Number of open-field center crossings by control (n = 10) and knockout (n = 5) animals; P = 0.28 by unpaired t test.