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. 2011 Nov 21;6(11):e28168. doi: 10.1371/journal.pone.0028168

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Beutler et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Lever presses during operant conditioning sessions by control (n = 10) and knockout (n = 5) animals across days; two-way, repeated-measures ANOVA: genotype effect F(1, 13) = 15.72, P = 0.002; day effect F(6, 78) = 10.90, P<0.001; genotype x day effect F(6,78) = 12.96, P<0.001 (###P<0.001); **P<0.01, ***P<0.001 compared to session 1 within genotype. (B) Latency to first lever press during operant conditioning sessions by control (n = 10) and knockout (n = 5) animals across days; two-way repeated measures ANOVA: genotype effect F(1, 13) = 38.75, P<0.001; day effect F(6, 78) = 2.26, P = 0.04; genotype x day effect F(6,78) = 8.04, P<0.001 (###P<0.001); **P<0.01, ***P<0.001 compared to session 1 within genotype. (C) Total number of head entries during operant conditioning sessions by control (n = 10) and knockout (n = 5) animals across days; two-way repeated measures ANOVA: genotype effect F(1, 13) = 10.14, P = 0.007; day effect F(6, 78) = 1.93, P = 0.08; genotype x day effect F(6,78) = 2.25, P = 0.04 (#P<0.05); *P<0.05, **P<0.01, ***P<0.001 compared to session 1 within genotype.