The LTED score predicts long-term disease outcome following adjuvant tamoxifen therapy. A-C) Patients in LOI164 (A), LOI181 (B), and MDACC298 (C) were dichotomized based on median LTED score, and Kaplan-Meier survival curves were compared using log-rank test. D-F) Patients in LOI164 (D), LOI181 (E), and MDACC298 (F) were censored at the five-year time point and analyzed as in (A-C).