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. 2011 Oct 27;12:526. doi: 10.1186/1471-2164-12-526

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Copyright ©2011 Hu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chromosome copy number variation or segmental duplications are present in environmental and clinical strains. CGH analysis revealed that strains A5-35-17 and JP1086 show copy number variation at chr 1 (whole chromosome) and 7 (segmental duplication), respectively, among 19 clinical and environmental isolates. The analysis of isolates from the AIDS patients revealed two, HC-4 and HC-6, with segmental duplications at chr 9 and chr 6, respectively. The "fuzzy" signal intensity for each chromosome in the HC-4 hybridization indicates that the genome of this strain is divergent from the genome of the reference strain H99. This pattern is seen with strains that differ in molecular subtype (VNII or VNB) from the VNI type of H99 [18]. The HC-6 strain was found to be diploid by FACS (Additional file 10) and this suggests that the strain may contain one intact copy of chr 6 and one copy with a central deletion.